IV Y-Site Compatibility Matrix
Verify compatibility before running concurrent continuous infusions or piggybacks through shared lumens. Prevent physical precipitation, catheter occlusion, and chemical drug degradation.
IV Y-Site Compatibility & Diluent Matrix
Cross-check multi-line infusions for precipitate formation, acid-base neutralization, and diluent safety.
Do NOT infuse these medications through the same Y-site lumen or IV extension set. Mixing in the line will cause visible/microscopic precipitation, catheter occlusion, or pharmacological inactivation.
Active Multi-Infusion Regimen
Select or deselect medications to inspect your concurrent bedside IV line plan.
Y-Site Compatibility Grid
Click any intersection cell to inspect the exact chemical mechanism and pH interaction.
| Medication | Norepinephrine | Fentanyl | Midazolam | Pantoprazole |
|---|---|---|---|---|
Norepinephrine (Noradrenaline) pH 3.0 – 4.5 | — | |||
Fentanyl Citrate pH 4.0 – 7.5 | — | |||
Midazolam HCl pH 3.0 – 3.6 | — | |||
Pantoprazole Sodium pH 9.0 – 10.5 | — |
Diluent Compatibility & Administration Protocols
Carrier fluid selection, light protection, and in-line filter requirements for active medications.
D5W preferred over NS to protect against oxidation. Incompatible with alkaline solutions (inactivated). Dedicated lumen recommended.
Synthetic opioid. Compatible with most vasoactive infusions; incompatible with Pentobarbital.
Acidic drug (pH ~3.3). Mixing with alkaline drugs (Pantoprazole, Bicarbonate, Furosemide) causes instantaneous heavy white precipitate.
Strongly alkaline (pH >9.5). Instantly causes cloudy precipitate when Y-sited with acidic sedatives (Midazolam, Dexmedetomidine) or antiemetics (Ondansetron).
Add Medications to Regimen
Search across 30+ emergency, ICU, and ward injectables commonly used across acute care facilities.